Combating the threat of pandemic influenza

drug discovery approaches

Publisher: Wiley-Interscience in Hoboken, NJ

Written in English
Published: Pages: 279 Downloads: 743
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Edition Notes

Statementedited by Paul F. Torrence.
LC ClassificationsRM
The Physical Object
Paginationxiii, 279 p. :
Number of Pages279
ID Numbers
Open LibraryOL22768240M
ISBN 109780470118795

Though a mild influenza pandemic, the Asian flu provided a reminder of the persisting threat of the global spread of emergent diseases. 7. – Hong Kong Flu It would be only a decade before the next global influenza pandemic, during which time there were few developments of note in terms of either medical science or by: In the flu season, the dominant strains were influenza type A (H3N2) and influenza type B viruses. A version of the virus responsible for .   If the threat of pandemic flu arises, stock up on key items so if an outbreak occurs in your area, you won’t have to leave your house. Pandemic flu commonly spreads in crowded areas, like stores. Have two weeks worth of food and water set aside. [19]%(5).   When you find yourself challenged by myopic colleagues about the waning risk of an H5N1 pandemic, cite the H3N8 example. I don't know if H5N1 will cause the next pandemic. It might. It might not. What I do know is that some strain of influenza will cause a pandemic. If you expect the unexpected—just as you would with any disaster—you and.

By Daniel R. Lucey The recent recognition of Zika as a Public Health Emergency of International Concern (PHEIC) by the World Health Organization raises the question of whether global pandemics are the "new normal". SARS, MERS, H1N1, Ebola and Zika are just a few examples of global health emergencies the world has seen in the last decade, and Dr. Daniel R. Lucey, an. Pandemic flu is a virulent human flu that causes a global outbreak, or pandemic, of serious illness. Because there is little natural immunity, the disease can spread easily from person-to-person. Currently, there is no pandemic flu. Most of us are familiar with seasonal influenza or the “flu,” a viral infection that, despite annual vaccinations, results in approximat   The problem with the NMS approach for combating a pandemic is that it relies on rushing all necessary local, state and federal resources to the scene of a disaster until it is “overwhelmed with. Influenza. An influenza pandemic may occur when an influenza virus radically changes and can easily infect humans, and against which people have little or no immunity. Pandemics have been recorded every ten to forty years dating back to the s, and likely long before then. There were three during the last century.

  At its peak, the – influenza pandemic (Spanish flu) incapacitated American cities and paralyzed the health care system. A 20th century outbreak of disease with calamitous effects in this country, Spanish flu is an apt case to influence current bioterrorism planning by: the pandemic of – The article analyzes the autumn outbreak and suggests that the portrayal of Krusen as a public health amateur or bumbling incompetent by various authors and multimedia documentaries is misleading. Furthermore, as the threat of epidemics by respiratory viruses—for instance, HPAI H5N1, H1N1, SARS, MERS, and Nipah—.   The influenza pandemic of was an event the world had begun preparing for at least five years before it happened. As Margaret Chan, the World Health Organization's Director-General, told a meeting of ASEAN health ministers shortly after the new pandemic virus appeared, ‘The world is better prepared for an influenza pandemic than at any time in history’ ().   The Looming Threat of Avian Flu Last year’s outbreak showed just how difficult it is to protect America’s agricultural system from devastating diseases. .

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Combating the Threat of Pandemic Influenza: Drug Discovery Approaches consolidates the latest information on diverse approaches into one comprehensive resource. It is an invaluable, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.

Combating Pandemic Threats. Infectious disease outbreaks represent a profound threat to global health, economic development and political stability. Therefore, it is crucial to adopt a universal outlook on disease surveillance and the management of outbreaks. anthrax, H5N1 influenza, HlN1 pandemic influenza, Ebola, Marburg, LuJo and.

Get this from a library. Combating the threat of pandemic influenza: drug discovery approaches. [Paul F Torrence;] -- This book discusses promising antiviral drug discovery strategies.

All researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public. Combating the Threat of Pandemic Influenza: Drug Discovery Approaches by PF Torrence (ed).

Wiley Intersci- ence, Hoboken, NJ, $ (hardcover). The threat of a human influenza pandemic has greatly increased over the past several years with the emergence of highly virulent avian influenza viruses, notably H5N1 viruses, which have infected humans in several Asian and European countries.

Previous influenza pandemics have. Summary This chapter contains sections titled: DAS (Fludase®): A Novel Influenza Virus Receptor Inactivator T‐ An Inhibitor of Influenza Virus Replication Inhibiting Viral Replication and.

To add immediacy, Combating the Threat of Pandemic Influenza might be entitled Combating the Threat of Seasonal Influenza. In the first decade of the new century, an ominous increase in the frequency of emergence of new antigenic variants of rapidly changing influenza viruses has been : W.

Paul Glezen. Research has identified three essential prerequisites for the start of a pandemic: transmission of a novel viral subtype to humans; viral replication causing disease in humans; and efficient human-to-human transmission of the virus.

Sincethe first two prerequisites have been met on four occasions; the most recent occurred early this year in Vietnam and Thailand. With H5N1 at or Cited by: 7. THE GREAT INFLUENZA Combating the threat of pandemic influenza book a fascinating book, not lacking in detail.

It is unlikely that the death count would have There are still aspects to the /19 "Spanish"flu pandemic that elude us. It likely originated in Kansas, not Spain.4/5(2K).

An influenza pandemic is an epidemic of an influenza virus that spreads on a worldwide scale and infects a large proportion of the world contrast to the regular seasonal epidemics of influenza, these pandemics occur irregularly – there have been five influenza pandemics during the last years.

Pandemics can cause high levels of mortality, with the Spanish flu. A ten-book series that examines status of preparations, implementation strategies, and other aspects of the US response to the threat of pandemic influenze Audio Back to the Future: The Influenza Revisited.

Advisers to the Nation on Science, Engineering, and Medicine. The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare.

Upon the authority of the charter granted to it by the. Robert G. Wallace, "Combating the Threat of Pandemic Influenza: Drug Discovery Approaches. Edited by Paul F.

Torrence.," The Quarterly Review of. The “flu” has become a popular catchall term to describe anything from a bad cold to stomach distress.

But real flu, influenza, is the defined illness that many public health officials dread n andannual estimates of deaths from flu-related complications in the United States ranged from 3, to 49, and more thanpeople are hospitalized.

The Threat of Pandemic Influenza: Are We Ready. Workshop Summary. Institute of Medicine (US) Forum on Microbial Threats; Knobler SL, Mack A, Mahmoud A, Lemon SM, editors.

Washington (DC): National Academies Press (US); The National Academies Collection: Reports funded by National Institutes of by: Background.

Emerging infectious diseases of pandemic potential, such as influenza viruses of animal origin and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), remain persistent threats to livelihoods, food security and health across Asia and the world.

The Pandemic Playbook (TPP) is committed to educating the public and global leadership concerning this growing threat which is capable of exterminating our species. Therefore understanding and analyzing epidemics and pandemics and their source emerging and re-emerging infectious diseases (EIDs), pathogens of pandemic potential, is the focus of TPP.

The US Centers for Disease Control and Prevention (CDC) partnered with Emory University to mark the th anniversary of the flu with a symposium about influenza pandemics: when and if they will strike, how ready the United States is to confront a pandemic, and how to do so.

A surge in human infections caused by avian influenza A H7N9 virus in China has prompted pandemic concerns and has focused attention on novel influenza A viruses.1 Sincemore than human beings infected with avian influenza A H7N9 virus, resulting from poultry exposures, have been reported during winter–spring epidemics in China.2–4 Low Cited by:   Influenza viruses have posed a continual threat to global public health since at least as early as the Middle Ages, resulting in an estimated 3–5 million cases of severe illness and ,–, deaths annually worldwide, according to a recent estimate [].Regional influenza epidemics occur on an annual basis, resulting in millions of illnesses and hospitalizations Cited by: 3.

Combatting influenza is a hallmark of Dr. Schuchat’s 30 years at CDC. In reflecting on the influenza pandemic, Dr. Schuchat says studying what happened can help us to better prepare the nation and the world for similar scenarios in the future.

National Strategy for Pandemic Influenza presents our approach to address the threat of pandemic influenza, whether it results from the strain currently in birds in Asia or another influenza virus.

It outlines how we intend to prepare, detect, and respond to a pandemic. It alsoFile Size: KB. In an influenza pandemic, the demand for health care services is anticipated to exceed the capacity of VHA facilities both to treat influenza patients and to sustain other health care services.

Projections based on the peak period of a severe like influenza pandemic suggest that facilities may have only one ICU bed for every four toFile Size: 2MB.

The Pandemic Influenza and Other Emerging Threats (PIOET) Unit supports two major lines of work: H5N1 Avian Influenza, and Emerging Pandemic Threats. H5N1 Avian I nfluenza: SinceUSAID has strengthened the capacities of more than 50 countries for monitoring the spread of H5N1 avian influenza among wild bird.

Laura Spinney’s absorbing study of the Spanish influenza, which killed almost million people, should make us glad the NHS exists Miranda Seymour Sun 4 Jun EDT Last modified Author: Miranda Seymour.

For centuries, novel strains of influenza have emerged to produce human pandemics, causing widespread illness, death, and disruption.

There have been four influenza pandemics in the past hundred years. During this time, globalization processes, alongside advances in medicine and epidemiology, have altered the way these pandemics are experienced.

Drawing on Cited by:   Given current uncertainties about the technique, waiting until the pandemic threat appears will simply be too late. Characteristics of a pandemic vaccine and vaccination schedule.

It is impossible to predict the dose (micrograms of HA) or the number of doses of vaccine needed for protection against pandemic by: There are a lot of tidbits about the influenza pandemic of Even dramatic series like Downton Abbey mention the event tragically.

But this book draws together information from a large number of sources and tells a more comprehensive story. The startling fact is that the combination of sources still exist today/5().

Department of Homeland Security (DHS), Department of Health and Human Services (HHS), and other organizations. Many of these national plans identify telecommuting as a key component of the national response to a pandemic influenza. Despite increasing adoption of telecommuting as aFile Size: 2MB.

Preparation measures for a biological threat or influenza pandemic focus on rapid quarantine, vaccines, developing antiviral treatments, and economic concerns (Brown, ; Ferguson et.

How much or how little any nation, state, community, business, or individual should prepare for an influenza pandemic has been subject of occasional debate.

Some advocates have questioned how the threat of a severe but unlikely influenza pandemic compares to that of other pressing public health and safety issues, and whether common resources.INFLUENZA PANDEMIC PREPAREDNESS - A CONCEPT PLAN TO PREPARE FOR THE CONTINGENCY OF A MAJOR GLOBAL PANDEMIC OF INFLUENZA CONTENTS SECTION I: threat of a major pandemic of influenza which could potentially have serious effects on the health of the human population.

Major pandemics have occurred in/The Pandemic and All-Hazards Preparedness and Advancing Innovation Act (PAHPAI) is legislation introduced and passed by the U.S. Congress in that aims to improve the nation's preparation and response to public health threats, including both natural threats and deliberate man-made threats.

A previous bill (with a near-identical name), the Pandemic and All Enacted by: the th United States Congress.